Design of ionic liquid 1,3-disulfonic acid imidazolium hydrogen sulfate as a dual-catalyst for the one-pot multi-component synthesis of 1,2,4,5-tetrasubstituted imidazoles

作者：Zolfigol Mohammad Ali^*; Khazaei Ardeshir; Moosavi Zare Ahmad Reza; Zare Abdolkarim; Asgari Zhila; Khakyzadeh Vahid; Hasaninejad Alireza

来源：Journal of Industrial and Engineering Chemistry, 2013, 19(3): 721-726.

DOI：10.1016/j.jiec.2012.10.014

• 1,3-Disulfonic acid imidazolium hydrogen sulfate {[Dsim]HSO4}
• Ionic liquid
• Imidazole
• 1,2,4,5-Tetrasubstituted imidazoles
• Multi-component reaction
• Solvent-free

Novel ionic liquid 1,3-disulfonic acid imidazolium hydrogen sulfate {[Dsim]HSO4} efficiently catalyzes the synthesis of 1,2,4,5-tetrasubstituted imidazoles via the one-pot multi-component condensation of benzyl with aldehydes, primary amines and ammonium acetate at 90 degrees C under solvent-free conditions. Dual hydrogen-bond donors can be used to direct the assembly of this catalyst and the efficiency of it.

• 出版日期2013-5-25