Disulfiram/copper complex inhibiting NF kappa B activity and potentiating cytotoxic effect of gemcitabine on colon and breast cancer cell lines

作者：Guo, Xiaoxia; Xu, Bing; Pandey, Shuchita; Goessl, Elisabeth; Brown, James; Armesilla, Angel L.; Darling, John L.; Wang, Weiguang^*

来源：Cancer Letters, 2010, 290(1): 104-113.

DOI：10.1016/j.canlet.2009.09.002

• NF kappa B
• Gemcitabine resistance
• Disulfiram
• Colorectal cancer
• Breast cancer

Most of the gemcitabine (dFdC) resistant cell lines manifested high NF kappa B activity. The NF kappa B activity can be induced by dFdC and 5-FU exposure. The chemosensitizing effect of disulfiram (DS), an anti-alcoholism drug and NF kappa B inhibitor, and copper (Cu) on the chemoresistant cell lines was examined. The DS/Cu complex significantly enhanced the cytotoxicity of dFdC (resistant cells: 12.2-1085-fold) and completely reversed the dFdC resistance in the resitant cell lines. The dFdC-induced NF kappa B activity was markedly inhibited by DS/Cu complex. The data from this study indicated that DS may be used in clinic to improve the therapeutic effect of dFdC in breast and colon cancer patients.

• 出版日期2010-4-1
• 单位南方医科大学