A bivariate survival model with compound Poisson frailty

作者：Wienke A^*; Ripatti S; Palmgren J; Yashin A

来源：Statistics in Medicine, 2010, 29(2): 275-283.

DOI：10.1002/sim.3749

• survival analysis
• correlated frailty model
• compound Poisson distribution
• cure fraction
• breast cancer

A correlated frailty model is suggested for analysis of bivariate time-to-event data. The model is an extension of the correlated power variance PVF) frailty model (correlated three-parameter frailty model) (J. Epidemiol. Biostat. 1999; 4:53-60). It is based on a bivariate extension of the compound Poisson frailty model in univariate survival analysis (Ann. Appl. Probab. 1992; 4:951-972). It allows for a non-susceptible fraction (of zero frailty) in the population, overcoming the common assumption in survival analysis that all individuals are susceptible to the event under study. The model contains the correlated gamma frailty model and the correlated inverse Gaussian frailty model as special cases. A maximum likelihood estimation procedure for the parameters is presented and its properties are studied in a small simulation study. This model is applied to breast cancer incidence data of Swedish twins. The proportion of women susceptible to breast cancer is estimated to be 15 per cent.

• 出版日期2010-1-30
• 单位河北医科大学