Afghan Hindu Kush: Where Eurasian Sub-Continent Gene Flows Converge

作者：Di Cristofaro Julie; Pennarun Erwan; Mazieres Stephane; Myres Natalie M; Lin Alice A; Temori Shah Aga; Metspalu Mait; Metspalu Ene; Witzel Michael; King Roy J; Underhill Peter A; Villems Richard; Chiaroni Jacques^*

来源：PLos One, 2013, 8(10): e76748.

DOI：10.1371/journal.pone.0076748

Despite being located at the crossroads of Asia, genetics of the Afghanistan populations have been largely overlooked. It is currently inhabited by five major ethnic populations: Pashtun, Tajik, Hazara, Uzbek and Turkmen. Here we present autosomal from a subset of our samples, mitochondrial and Y- chromosome data from over 500 Afghan samples among these 5 ethnic groups. This Afghan data was supplemented with the same Y-chromosome analyses of samples from Iran, Kyrgyzstan, Mongolia and updated Pakistani samples (HGDP-CEPH). The data presented here was integrated into existing knowledge of pan-Eurasian genetic diversity. The pattern of genetic variation, revealed by structure-like and Principal Component analyses and Analysis of Molecular Variance indicates that the people of Afghanistan are made up of a mosaic of components representing various geographic regions of Eurasian ancestry. The absence of a major Central Asian-specific component indicates that the Hindu Kush, like the gene pool of Central Asian populations in general, is a confluence of gene flows rather than a source of distinctly autochthonous populations that have arisen in situ: a conclusion that is reinforced by the phylogeography of both haploid loci.

• 出版日期2013-10-18