Atraumatic Osteonecrosis After Estrogen Replacement Therapy Associated with Low Protein S Level in a Patient with Turner Syndrome

作者：Ureten Kemal^*; Ozturk M Akif; Bostanci Ahmet; Ceneli Ozcan; Oezbek Mustafa; Haznedaroglu Ibrahim C

来源：Clinical and Applied Thrombosis/Hemostasis, 2010, 16(5): 599-601.

DOI：10.1177/1076029609339746

• osteonecrosis
• protein S deficiency
• estrogen

Atraumatic osteonecrosis has been associated with a variety of clinical conditions including corticosteroid usage, alcoholism, infections, hyperbaric events, storage disorders, marrow-infiltrating diseases, coagulation defects, and some autoimmune diseases. Osteonecrosis due to thrombophilia is an extremely rare condition with only few cases reported previously in the literature. Hormone-replacement therapies cause increased risk of venous thrombosis, probably by causing a synergistic effect with inherited clotting defects. In this article, we report a young female with Turner syndrome, who developed avascular necrosis of the femoral head during treatment with oral estrogen, which was associated with low protein S levels.

• 出版日期2010-10