Manufacturing synthesis of 5-hydroxy-2-methyl-1H-indole

作者：Huang Yun Sheng^*; Zhang Wen Qing; Zhang Xu; Wang Jian Zhong

来源：Research on Chemical Intermediates, 2010, 36(8): 975-983.

DOI：10.1007/s11164-010-0210-x

• 5-Hydroxy-2-methyl-1H-indole
• Nenitzescu
• Benzoquinone
• Aminocrotonate

The manufacturing synthesis of 5-hydroxy-2-methyl-1H-indole is described and two synthetic methods were used and the results discussed. Two small and three large runs with Nenitzescu's method were analyzed and results reported with different reaction conditions. Manufacturing issues encountered were discussed. Production scale of more than 60 kg of the 5-hydroxy-2-methyl-1H-indole-3-carboxylic acid ethyl ester and over 20 kg of the 5-hydroxy-2-methyl-1H-indole were achieved. Based on these results, larger scale manufacturing of this product or similar products based on the optimized conditions is feasible.

• 出版日期2010-11
• 单位广东医科大学