Asymptomatic Profound Sinus Bradycardia (Heart Rate <= 45) in Non-small Cell Lung Cancer Patients Treated with Crizotinib

作者：Ou Sai Hong Ignatius^*; Azada Michele; Dy Joni; Stiber Jonathan A

来源：Journal of Thoracic Oncology, 2011, 6(12): 2135-2137.

DOI：10.1097/JTO.0b013e3182307e06

• Sinus bradycardia
• Crizotinib (PF02341066)
• Pharmacodynamic effect
• Non-small cell lung cancer

Crizotinib, a dual MET/ALK inhibitor, is now in advanced clinical development for the treatment of anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC). We have observed several patients who developed profound but asymptomatic sinus bradycardia (HR <= 45) during the course of crizotinib treatment. Herein, we describe the clinical characteristics of three separate patients enrolled in the A8081001 trial (NCT00585195) who developed asymptomatic profound sinus bradycardia with their accompanying electrocardiogram tracings.

• 出版日期2011-12