An OFF-ON-OFF type fluorescent probe based on a naphthalene derivative for Al3+ and F- ions and its biological application

作者：Ren, Yanpeng; Han, Juan; Wang, Yun; Tang, Xu; Wang, Lei^*; Ni, Liang^*

来源：Luminescence, 2018, 33(1): 15-21.

DOI：10.1002/bio.3366

• Al3+ and F-
• cell detection
• fluorescent probe
• OFF-ON-OFF type

A novel fluorescent probe-based naphthalene Schiff, 1-(C2-glucosyl-ylimino-methyl)-naphthalene-2-ol (L) was synthesized by coupling d-glucosamine hydrochloride with 2-hydroxy-1-naphthaldehyde. It exhibited excellent selectivity and highly sensitivity for Al3+ in ethanol with a strong fluorescence response, while other common metal ions such as Pb2+, Mg2+, Cu2+, Co2+, Ni2+, Cd2+, Fe2+, Mn2+, Hg2+, Li+, Na+, K+, Fe3+, Cr3+, Zn2+, Ag+, Ba2+ and Ca2+ did not cause the same fluorescence response. The probe selectively bound Al3+ with a binding constant (K-a) of 5.748x10(3)M(-1) and a lowest detection limit (LOD) of 4.08nM. Moreover, the study found that the fluorescence of the L-Al3+ complex could be quenched after addition of F- in the same medium, while other anions, including Cl-, Br-, I-, NO2-, NO3-, ClO4-, CO32-, HCO3-, SO42-, HSO4-, CH3COO-, PO43-, HPO42-, S2- and S2O32- had nearly no influence on probe behaviour. Binding of the [L-Al3+] complex to a F- anion was established by different fluorescence titration studies, with a detection limit of 3.2nM in ethanol. The fluorescent probe was also successfully applied in the imaging detection of Al3+ and F- in living cells.

• 出版日期2018-2
• 单位江苏大学