A novel one-pot synthesis of 3-carbomethoxy-4-arylfuran-2-(5H)-ones from ketones using [hydroxy(tosyloxy)iodo]benzene

作者：Karade Nandkishor N^*; Gampawar Sumeet V; Kondre Jeevan M; Shinde Sandeep V

来源：Tetrahedron Letters, 2008, 49(28): 4402-4404.

DOI：10.1016/j.tetlet.2008.05.012

• hypervalent iodine
• gamma-lactone
• potassium monomethyl malonate
• enolisable ketone

A novel one-pot procedure for the synthesis of 3-carbomethoxy-4-aryl furan-2-(5H)-ones is reported via alpha-tosyloxylation of enolisable ketones with [hydroxy(tosyloxy)iodo]benzene, followed by treatment with potassium monomethyl malonate and K(2)CO(3).

• 出版日期2008-7-7