Limitations and information needs for engineered nanomaterial-specific exposure estimation and scenarios: recommendations for improved reporting practices

作者：Clark Katherine; van Tongeren Martie; Christensen Frans M; Brouwer Derk; Nowack Bernd; Gottschalk Fadri; Micheletti Christian; Schmid Kaspar; Gerritsen Rianda; Aitken Rob; Vaquero Celina; Gkanis Vasileios; Housiadas Christos; Lopez de Ipina Jesus Maria; Riediker Michael^*

来源：Journal of Nanoparticle Research, 2012, 14(9): 970.

DOI：10.1007/s11051-012-0970-x

• Nanomaterials
• Exposure assessment
• Risk assessment
• Modeling
• REACH
• Environmental and health effects

The aim of this paper is to describe the process and challenges in building exposure scenarios for engineered nanomaterials (ENM), using an exposure scenario format similar to that used for the European Chemicals regulation (REACH). Over 60 exposure scenarios were developed based on information from publicly available sources (literature, books, and reports), publicly available exposure estimation models, occupational sampling campaign data from partnering institutions, and industrial partners regarding their own facilities. The primary focus was on carbon-based nanomaterials, nano-silver (nano-Ag) and nano-titanium dioxide (nano-TiO2), and included occupational and consumer uses of these materials with consideration of the associated environmental release. The process of building exposure scenarios illustrated the availability and limitations of existing information and exposure assessment tools for characterizing exposure to ENM, particularly as it relates to risk assessment. This article describes the gaps in the information reviewed, recommends future areas of ENM exposure research, and proposes types of information that should, at a minimum, be included when reporting the results of such research, so that the information is useful in a wider context.

• 出版日期2012-9