Acute flavanol consumption improves the cerebral vasodilatory capacity in college-aged African Americans

作者：Hurr Chansol; Harrison Michelle L; Brothers R Matthew

来源：Experimental Physiology, 2015, 100(9): 1030-1038.

DOI：10.1113/EP085269

New Findings
What is the central question of this study? The purpose was to determine whether acute flavanol consumption improves cerebral vasodilatory capacity during rebreathing-induced hypercapnia in African Americans.
What is the main finding and its importance? The reduced cerebral vasodilatory response to hypercapnia in young healthy African Americans was improved acutely following consumption of a flavanol-rich beverage. This may have important clinical implications regarding racial differences in cerebrovascular disease risk and possible interventional approaches to offset this risk.
African Americans (AAs) have increased risk for cardiovascular and cerebrovascular disease. African Americans have attenuated cerebral vasodilator capacity during hypercapnia relative to Caucasian Americans (CAs). This study tested the hypothesis, using a placebo-controlled crossover design, that acute flavanol consumption improves the range of change in cerebral vascular conductance [CVCI, (a)] and the maximal CVCI (y0) achieved during rebreathing-induced increases in end-tidal carbon dioxide tension. Fourteen college-aged AAs and 14 CAs participated. Both a and y0 were lower in AAs prior to flavanols (for a, AAs, 46 +/- 16versus CAs, 74 +/- 18% CVCI, P<0.001; and for y0, AAs, 151 +/- 18versus CAs, 176 +/- 20% CVCI, P=0.002); however, these variables were increased after flavanols such that there were no differences between groups (for a, AAs, 64 +/- 19versus CAs, 72 +/- 22% CVCI, P=0.35; and for y0, AAs, 166 +/- 22versus CAs, 176 +/- 22% CVCI, P=0.26). Both a and y0 were also lower in AAs prior to placebo (for a, AAs, 52 +/- 19versus CAs, 76 +/- 15% CVCI, P=0.002; and for y0, AAs, 156 +/- 20versus CAs, 177 +/- 21% CVCI, P=0.015), and these differences remained following placebo (for a, AAs, 52 +/- 17versus CAs, 80 +/- 20% CVCI, P<0.001; and for y0, AAs, 152 +/- 18versus CAs, 181 +/- 25% CVCI, P=0.003).These data suggest that acute flavanol consumption improves cerebral vasodilatory capacity during hypercapnia in AAs.

• 出版日期2015-9-1