A pH-sensitive and biodegradable supramolecular hydrogel constructed from a PEGylated polyphosphoester-doxorubicin prodrug and α-cyclodextrin

作者：Li, Fei; He, Jinlin^*; Zhang, Mingzu; Ni, Peihong

来源：Polymer Chemistry, 2015, 6(28): 5009-5014.

DOI：10.1039/c5py00620a

• BLOCK-COPOLYMER HYDROGELS
• DRUG-DELIVERY
• POLYPRODRUG AMPHIPHILES
• FACILE SYNTHESIS
• RELEASE
• MICELLES
• PROGRESS
• DESIGN
• DRIVEN

An acid-labile and PEGylated polyphosphoester-doxorubicin prodrug (PBYP-g-PEG-g-DOX) was prepared via a combination of ring-opening polymerization (ROP) and Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) "click" chemistry. The resulting multifunctional prodrug was then used to interact with alpha-cyclodextrin (alpha-CD) to fabricate a novel supramolecular hydrogel based on inclusion complexation.

• 出版日期2015
• 单位苏州大学