Different A-Type Natriuretic Peptide Level in Five Strains of Mice

作者：Mifune Hiroharu^*; Nishi Yoshihiro; Tajiri Yuji; Yabuki Akira

来源：Journal of Veterinary Medical Science, 2012, 74(4): 499-502.

DOI：10.1292/jvms.11-0451

• A-type natriuretic peptide
• cardiocyte
• immunohistochemistry
• mouse strain
• ultrastructural morphometry

Atrial (A-type) natriuretic peptide (ANP) is vasodilative hormone involved in the regulation of blood pressure and volume homeostasis. In this study, we examined the differences of the auricular and plasma ANP distribution by immunohistochemistry, ultrastructural morphometry, and radioimmunoassay in five strains of mice. The AN P-immunoreactivities of the auricle were most intense in ICR, and moderate in C57BL/6J and C3H/HeN, and weakest in BALB/cA and DBA/2Cr. The number of ANP-granules was greatest in ICR followed by C57BL, C3H or BALB/c, and DBA/2 mice, in this order. The auricular ANP content was highest in ICR, but the plasma ANP concentration was comparable in all strains. The present study demonstrates that there are differences in the AN P circulating system between five strains.

• 出版日期2012-4