Assessment of Benefits of a Universal Screen for Maternal Alcohol Use during Pregnancy

作者：Gifford Anne E; Farkas Kathleen J; Jackson Leila W; Molteno Christopher D; Jacobson Joseph L; Jacobson Sandra W; Bearer Cynthia F^*

来源：Birth Defects Research Part A: Clinical and Molecular Teratology , 2010, 88(10): 838-846.

DOI：10.1002/bdra.20731

• fetal alcohol spectrum disorder
• meconium
• fatty acid ethyl esters
• newborn screening
• benefits
• maternal alcohol use

INTRODUCTION: The objective of this report is to estimate the benefits of universal meconium screening for maternal drinking during pregnancy. Fetal alcohol spectrum disorder (FASD), including its most severe manifestation fetal alcohol syndrome (FAS), is preventable and remains a public health tragedy. The incidences of FAS and FASD have been conservatively estimated to be 0.97 and 10 per 1000 births, respectively. Meconium testing has been demonstrated to be a promising at-birth method for detection of drinking during pregnancy. METHODS: The current costs of FAS and FASD, alcohol treatment programs, and meconium screening were estimated by literature review. Monetary values were converted roughly to equal dollars in 2006. RESULTS: Costs of adding meconium analysis to the current newborn screening program and of treatment for the identified mothers were estimated and compared to potential averted costs that may result from identification and intervention for mothers and affected infants. Three potential maternal treatment strategies are analyzed. Depending on the treatment type, the savings may range from $6 to $97 for every $1 spent on screening and treatment. DISCUSSION: It needs to be emphasized, however, that such screening is premature and that to be effective this screening can be implemented only if there is a societal willingness to institute prevention and intervention programs to improve both women's and children's health. Future research should be directed at improving detection and developing in-depth prevention and remedial intervention programs. A thorough consideration of the ethical issues involved in such a screening program is also needed. Birth Defects Research (Part A) 88:838-846, 2010.

• 出版日期2010-10