A procedure for the preparation and isolation of nucleoside-5 '-diphosphates

作者：Korhonen Heidi J; Bolt Hannah L; Hodgson David R W^*

来源：Beilstein Journal of Organic Chemistry, 2015, 11: 469-472.

DOI：10.3762/bjoc.11.52

• NDP synthesis
• nucleic acids
• nucleoside-5'-diphosphate
• phosphorylation

Tris[bis(triphenylphosphoranylidene)ammonium] pyrophosphate (PPN pyrophosphate) was used in the S(N)2 displacements of the tosylate ion from 5'-tosylnucleosides to afford nucleoside-5'-diphosphates. Selective precipitation permitted the direct isolation of nucleoside-5'-diphosphates from crude reaction mixtures.

• 出版日期2015-4-10