EQ-5D studies in cardiovascular diseases in eight Central and Eastern European countries: a systematic review of the literature

作者：Batog Paulina; Rencz Fanni; Pentek Marta; Gulacsi Laszlo; Filipiak Krzysztof J; Rupel Valentina Prevolnik; Simon Judit; Brodszky Valentin; Baji Petra; Zavada Jakub; Petrova Guenka; Rotar Alexandru; Golicki Dominik^*

来源：Kardiologia Polska, 2018, 76(5): 860-870.

DOI：10.5603/KP.a2018.0033

• health-related quality of life
• EQ-5D
• cardiovascular diseases
• ischaemic heart disease
• Central and Eastern Europe

Background: The measurement of health-related quality of life (HRQoL) by validated generic instruments, such as EQ-5D, has become an increasingly important tool for the assessment of health care in a wide range of diagnoses. Aim: We aimed to systematically review EQ-5D literature on cardiovascular diseases in eight Central and Eastern European (CEE) countries.
Methods: A structured literature search was conducted in MEDLINE, EMBASE, Web of Science, CINAHL, PsycINFO, Cochrane Library, and the EuroQol website up to November 2016. Original cardiovascular-related studies that reported EQ-5D results were included.
Results: Of the 36 papers, 17 reported EQ-5D index scores. Most studies were performed in Poland (n = 24, 67%). The most common diagnosis regarding the number of publications and population size was ischaemic heart disease (n = 13, N = 6394), followed by atrial fibrillation (n = 4, N = 1052). The average EQ-5D index scores ranged from 0.61 to 0.88 and from 0.66 to 0.95 for patients before and after cardiac procedure/surgery, respectively (including angioplasty, coronary artery bypass grafting, ablation, surgical correction of septal defects, transcatheter aortic valve implantation [TAVI]). In all studies baseline scores were lower than the repeated assessments after the procedure, with the most substantial improvement of 0.24 in high-risk elderly patients after TAVI. Studies which did not assess invasive treatment reported mean EQ-5D index scores ranging from 0.18 to 0.80
Conclusions: The number of cardiovascular-related studies reporting HRQoL using EQ-5D has consistently increased in CEE countries over the past decade and is outstanding compared with other clinical fields. The EQ-5D index and EQ VAS scores varied based on the disease severity, patient characteristics, and treatment protocol.

• 出版日期2018