科研之友
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摘要
Activation of cardiac sympathetic nerves alters ventricular repolarization; however, these changes remain poorly characterized. The goal of this study was to examine effects of sympathetic stimulation on repolarization to identify electrocardiographic markers of sympathetic activation. Pigs underwent median sternotomy and bilateral thoracotomy to expose the stellate ganglia. Changes in T-wave duration, amplitude, repolarization vector, and time from peak to end (Tp-Te) were continuously monitored. Within 15 seconds of unilateral left or right stellate ganglion (LSG/RSG) stimulation, T-wave amplitude increased 6- and 4.5-fold, respectively, in lead aVF. T-wave duration and Tp-Te both increased 200% during LSG stimulation but only 50% and 30%, respectively, with RSG stimulation. During LSG stimulation, frontal and horizontal T-wave vectors, respectively, changed from 1.9 degrees +/- 22.8 degrees and 333.8 degrees +/- 9.7 degrees at baseline to 83.4 degrees +/- 3.9 degrees (inferiorly) and 306.7 degrees +/- 1.8 degrees (posteriorly). During RSG stimulation, frontal and horizontal T-wave vectors changed from 348.2 degrees +/- 21.6 degrees and 333.8 degrees +/- 10.3 degrees before stimulation to 280.7 degrees +/- 4.6 degrees (superiorly) and 118.1 degrees +/- 5.6 degrees (anteriorly). During stellate stimulation, T-wave vectors are displaced to angles specific for LSG activation (posteroinferiorly) or RSG activation (anterosuperiorly); T-wave amplitude, duration, and Tp-Te increase; and ST-duration decreases. Displaced repolarization vector and changes in T-wave morphometrics provide a novel marker of unilateral sympathetic nerve stimulation.
- 出版日期2011-12
- 单位UCLA
