Access to chiral tertiary amines via the iridium-catalyzed asymmetric hydrogenation of enamines

作者：Cheruku Pradeep; Church Tamara L; Trifonova Anna; Wartmann Thomas; Andersson Pher G^*

来源：Tetrahedron Letters, 2008, 49(51): 7290-7293.

DOI：10.1016/j.tetlet.2008.10.035

• Asymmetric catalysis
• Hydrogenation
• Enamines
• Chiral tertiary amines

The asymmetric hydrogenation of N,N-dialkyl and N-alkyl-N-aryl enamines to chiral tertiary amines was studied. All the N,P-ligated iridium complexes investigated were active catalysts for the reaction, but only those with bicycle-supported oxazoline-phosphine ligands gave reasonable stereoinduction. The best catalyst produced a range of chiral tertiary amines in up to 87% ee.

• 出版日期2008-12-15