A convenient method for the synthesis of cyclophosphamide analogues

作者：Zhang Liuji; Qu Lingbo; Zhang Baojun; Chen Xiaolan^*; Zhao Yufen

来源：Phosphorus, Sulfur, and Silicon and the Related Elements, 2008, 183(2-3): 799-803.

DOI：10.1080/10426500701808200

• cyclophosphamide analogues
• N,N-di-(2-chloro)ethylaminophosphorodichloridate
• paeonia

Several new 2-[bis(2-chloroethyl)amino)]-7-methoxyl-3-alkyl-4-methyl-1,3,2-benzoxazaphosphorin-2-oxides(3a-e) have been synthesized by cyclic condensation of bis(2-chloroethyl)amino phosphoryl dichloride and 2-(1-alkylamino) ethyl-4inethoxylphenol. The title compounds are characterized by NMR, ESI-Q-TOF and ESI-MS.

• 出版日期2008-3
• 单位郑州大学; 河南工业大学