Long-Term (%26gt;= 10 Years) Safety of Percutaneous Treatment of Unprotected Left Main Stenosis With Drug-Eluting Stents

作者：Sheiban Imad; Moretti Claudio; D' Ascenzo Fabrizio; Chieffo Alaide; Taha Salma; Connor Stephen O; Chandran SujaySubash; de la Torre Hernandez J M; Chen Sl; Varbella Ferdinando; Omede Pierluigi; Iannaccone Mario; Meliga Emanuele; Kawamoto Hiroyoshi; Montefusco Antonio; Mervyn Chong; Garot Philippe; Sin Lin; Gasparetto Valeria; Abdirashid Mohamed; Cerrato Enrico; Zoccai Giuseppe Biondi; Gaita Fiorenzo; Escaned Javier; Smith David Hiddick; Lefevre Thierry

来源：American Journal of Cardiology, 2016, 118(1): 32-39.

DOI：10.1016/j.amjcard.2016.04.007

Percutaneous coronary intervention (PCI) of unprotected left main disease (ULM) with drug-eluting stents (DES) is hampered by lack of information on long-term (1.0 years) safety data. All patients treated with PCI on ULM in 9 international centers with at least 10 years follow-up were enrolled. Baseline and procedural features were recorded. Repeat PCI (re-PCI) on ULM at 10 years was the primary end point. Secondary end points included major adverse cardiac events and its components (cardiac and noncardiac death, myocardial infarction, re-PCI not on ULM, and stent thrombosis). Sensitivity analysis was performed according to the presence of isolated ULM disease: 284 patients were enrolled. A total of 70 patients (21%) performed a re-PCI on ULM, 39 in the first year, and 31 between 1 and 10 years (only 5 overall performed for acute coronary syndrome). Patients with re-PCI on ULM did not show differences in baseline and procedural features, or experience higher rates of cardiovascular death (12% vs 11%, p 0.65), myocardial infarction (11% vs 6%, p 0.56), or of re-PCI on non-ULM disease (31% vs 27%, p 0.76) compared with those without re-PCI on ULM. At Kaplan Meier analysis, patients with PCI in other coronary vessels were at higher risk of major adverse cardiac events, driven by target vessel revascularization (20.4% vs 32.9%, p 0.009), as confirmed at multivariate analysis (stenosis other than LM; hazard ratio 2, 1.4 to 2.7, all CI 95%). In conclusion, despite of using first generation stents, PCI on ULM is safe, with low rates of recurrent events due to index revascularization. Progression of atherosclerotic lesions on other coronary vessels represents the only independent predictive factor for prognosis.

• 出版日期2016-7-1
• 单位南京医科大学