科研之友
微信
新浪微博
Facebook
分享链接
摘要
Caveoliu-1 is a target for academic and pharmaceutical research due to its many cellular roles and associated diseases. We report peptide W147 (1), a small, high-affinity, selective disrupter of caveolin-1 oligomers. Developed and optimized through screening and analysis of synthetic peptide libraries, ligand 1 has 7500 -fold improved affinity compared to its T20 parent ligand and an 80% decrease in sequence length. Ligand 1 will permit targeted study of caveoliri-1 function.
- 出版日期2016-4-28
