A fast and efficient deprotection of aldehydes from acylals using a Wells-Dawson heteropolyacid catalyst (H6P2W18O62 center dot 24H(2)O)

作者：Romanelli GP; Autino JC^*; Baronetti G; Thomas HJ

来源：Synthetic Communications, 2004, 34(21): 3909-3914.

DOI：10.1081/SCC-200034783

• acylal
• aldehyde
• 1,1-diacetate
• heteropolyacid
• protecting group
• Wells-Dawson catalyst

A rapid and efficient method for the deprotection of aldehyde l,l-diacetates is described. The reaction was carried out using a Wells-Dawson type catalyst supported on silica. The catalyst, used in 1% molar quantity, is easily recoverable and reusable and maintains the activity after its use in four consecutive reaction batches. The yield of the deprotection was 92-100% (15 examples including nitrobenzaldehyde l, l-diacetates). Reaction conditions involve short times and the use of toluene as the solvent; isolation is simple and the products are nearly pure.

• 出版日期2004