Up-Regulation of CCT8 Related to Neuronal Apoptosis after Traumatic Brain Injury in Adult Rats

作者：Wu, Xiaohong; Zhang, Haiyan; Chen, Dongjian; Song, Yan; Qian, Rong; Chen, Chen; Mao, Xingxing; Chen, Xinlei; Zhang, Weidong; Shao, Bai; Shen, Jianhong; Yan, Yaohua; Wu, Xinmin; Liu, Yonghua^*

来源：Neurochemical Research, 2015, 40(9): 1882-1891.

DOI：10.1007/s11064-015-1683-1

• Traumatic brain injury
• Neuronal apoptosis
• CCT8

Traumatic brain injury (TBI) initiates a series of neurochemical and signaling changes that could eventually lead to neuronal apoptosis. Recent studies indicated that mature neurons cell cycle re-enter played a crucial role in neuronal apoptosis. In this study, we identified that the chaperonin containing TCP-1, subunit 8 (CCT8), as a member of class II chaperonins, was significantly upregulated following TBI. Moreover, double immunofluorescence staining revealed that CCT8 was co-expressed with neuronal nuclei (NeuN). Besides, co-localization of CCT8/active caspase 3 was detected in NeuN. We also examined the expression profiles of active caspase 3 whose changes were correlated with the expression of CCT8. All our findings suggested that CCT8 might be involved in the pathophysiology of brain after TBI.

• 出版日期2015-9
• 单位南通大学