Alstoniaphyllines A-C, Unusual Nitrogenous Derivatives from the Bark of Alstonia macrophylla

作者:Cheenpracha Sarot*; Ritthiwigrom Thunwadee; Laphookhieo Surat
来源:Journal of Natural Products, 2013, 76(4): 723-726.
DOI:10.1021/np3006937

摘要

Chemical investigation of an alkaloidal extract of Alstonia macrophylla bark led to the isolation and identification of two new nitrogenous derivatives, alstoniaphyllines A (1) and B (2), a new indole alkaloid, alstoniaphylline C (4), and eight known alkaloids (3, 5-11). Alstonisine (9) exhibited antiplasmodial activity against Plasmodium falciparum, with an IC50 of 7.6 mu M.

  • 出版日期2013-4