Altered [Tc-99m]Tc-MDP biodistribution from neutron activation sourced Mo-99

作者：Demeter Sandor^*; Szweda Roman; Patterson Judy; Grigoryan Marine

来源：Journal of Radioanalytical and Nuclear Chemistry, 2018, 316(2): 619-627.

DOI：10.1007/s10967-018-5826-0

• Biodistribution
• Radiopharmaceutical
• Quality control
• Neutron activation
• Mo-99
• Pertechnetate

Given potential worldwide shortages of fission sourced Mo-99/Tc-99m medical isotopes there is increasing interest in alternate production strategies. A neutron activated Mo-99 source was utilized in a single center phase III open label study comparing Tc-99m, as Tc-99m Methylene Diphosphonate ([Tc-99m]Tc-MDP), obtained from solvent generator separation of neutron activation produced Mo-99, versus nuclear reactor produced Mo-99 (e.g., fission sourced) in oncology patients for which an [Tc-99m]Tc-MDP bone scan would normally have been indicated. Despite the investigational [Tc-99m]Tc-MDP passing all standard, and above standard of care, quality assurance tests, which would normally be sufficient to allow human administration, there was altered biodistribution which could lead to erroneous clinical interpretation. The cause of the altered biodistribution remains unknown and requires further research.

• 出版日期2018-5