Promoter polymorphism (-590, T/C) of interleukin 4 ( IL4) gene is associated with rheumatoid arthritis: An updated meta-analysis

作者：Park Hyun Kyung; Kim Su Kang; Kweon Hae Yong; Lee Kwan Gill; Arasu Mariadhas Valan; Kim Young Ock

来源：Saudi Journal of Biological Sciences, 2017, 24(2): 444-449.

DOI：10.1016/j.sjbs.2016.01.013

• Interleukin 4
• Polymorphism
• Rheumatoid arthritis
• Association study
• Meta-analysis

Rheumatoid arthritis (RA) is a chronic disease. It causes chronic inflammation of the joint. Recent studies suggested that interleukin 4 (IL4) contributes to susceptibility and severity of rheumatoid arthritis (RA). Especially, it was reported that promoter polymorphism (-590, T/C) of IL4 gene has been associated with susceptibility of RA. The aim of present study was to investigate whether the promoter polymorphism (-590, T/C) of IL4 gene is associated with the susceptibility of RA using metaanalysis. And in order to perform meta-analysis, comprehensive meta analysis program was used. Genetic models (co-dominant, dominant, recessive, and allele) were used to determine odds ratios (ORs), 95% confidence intervals (CIs), and P values. Nine case-control studies with case and control design were included in thismeta-analysis. Overall, meta-analysis revealed a strong associationwith susceptibility of RA [ OR= 1.303, 95% CI= 1.093-1.554, P= 0.003 in allele model (C vs. T); OR= 1.247, 95% CI= 1.054-1.474, P= 0.010 in dominant model (CC vs. CT+ TT); OR= 2.148, 95% CI= 1.263-3.651, P= 0.005 in recessive model (CC + CT vs. TT)]. Our data demonstrated that promoter polymorphism (-590, T/C) of IL4 gene may be contributed to susceptibility ofRA. However, more studies with a larger sample size are needed to provide more precise evidence. (c) 2016 The Authors. Production and hosting by Elsevier B. V. on behalf of King Saud University. This is an open access article under theCCBY-NC-NDlicense (http://creativecommons.org/licenses/by-nc-nd/4.0/).

• 出版日期2017-2