An efficient one-pot synthesis and in vitro antimicrobial activity of new pyridine derivatives bearing the tetrazoloquinoline nucleus

作者：Mungra Divyesh C; Patel Manish P; Patel Ranjan G^*

来源：ARKIVOC, 2009, 64-74.

• 2-Amino-3-cyano-4-tetrazoloquinolinylpyridine
• tetrazolo[1,5-a]quinoline-4-carbaldehyde
• one-pot synthesis
• antimicrobial activity
• MIC

A new series of 2-amino-3-cyano-4-tetrazoloquinolinylpyridine derivatives has been synthesized by the one-pot cyclocondensation reaction of a tetrazolo[1,5-a]quinoline-4-carbaldehyde, malononitrile, a heterocyclic/aromatic methyl ketone and ammonium acetate. All the synthesized compounds were subjected to in vitro antimicrobial screening against a panel of pathogenic strains of bacteria and fungi. Some of the compounds were found to be equipotent or more potent than commercial antibiotics as evident from the results.

• 出版日期2009