A convenient method for the preparation of mono- and bis-substituted photochromic bis(benzothienyl)perfluorocyclopentenes via regioselective Friedel-Crafts acylation

作者：Bogacheva A M^*; Yarovenko V N; Levchenko K S; Kobeleva O I; Valova T M; Barachevsky V A; Struchkova M I; Shmelin P S; Krayushkin M M; Charushin V N

来源：Tetrahedron Letters, 2012, 53(44): 5948-5951.

DOI：10.1016/j.tetlet.2012.08.111

• Regioselective Friedel-Crafts acylation
• Bis(benzothienyl)hexafluorocyclopentenes
• Photochromes
• Thiazoles
• Benzofurans

The regioselective Friedel-Crafts acylation of 1,2-bis(2-methylbenzo[b]thien-3-yl)hexafluorocyclopentene was developed. Depending on the reaction conditions, mono- or bis(bromoacetyl) derivatives are formed as single products in good yields. Further heterocyclizations involving alpha-bromoketone moieties gave a series of new photochromic compounds.

• 出版日期2012-10-31