A Novel DNA Biosensor Modified with Hollow Gold Nanoparticles

作者：Bo Yang^*; Yan Qing; Meng Qi; Hu Ying; Huang Shasheng

来源：Acta Chimica Sinica, 2010, 68(7): 672-678.

• hollow gold nanoparticles
• ssDNA
• sensor

A novel DNA biosensor was fabricated by modifying ssDNA, cytochrome c, L-cysteine, novel material hollow gold nanoparticles and Chitosan on the surface of glassy carbon electrode. The hollow gold nanoparticles (HGNs) were characterized by violet spectroscopy and transmission electron microscopy. The behavior of the DNA biosensor was investigated by circle voltammetry, impedance spectrum. The morphologic differences among each layer of the DNA biosensor were also observed by atomic force microscope. Results revealed that the amount of adsorbed DNA was 1.672 x 10(-10) mol.cm(-2). It could be concluded that the modified electrode could be used to detect DNA in the event of hybridization with the indicator daunomycin by differential pulse voltammetry (DPV).

• 出版日期2010-4-14
• 单位上海师范大学