An Efficient Synthesis of 1,3-Diarylbenzo[f]quinolines from 2-Halogenated Acetophenone, Aromatic Aldehyde, and Naphthalen-2-Amine Catalyzed by Iodine

作者：Wang Xiang Shan^*; Li Qing; Zhou Jie; Tu Shu Jiang

来源：Journal of Heterocyclic Chemistry, 2009, 46(6): 1222-1228.

DOI：10.1002/jhet.211

The three-component reaction of aromatic aldehyde, naphthalen-2-amine and 2-halogenated acetophenone in THF catalyzed by 5 mol % iodine at reflux unexpectedly gave 1,3-diarylbenzo[f]quinolines, with halogen losing in the formation of the products. The formation of unexpected 1,3-diarylbenzo[f]quinolines was tentatively explained by Cram's rule to one of the steps in the mechanism.

• 出版日期2009-11
• 单位江苏师范大学