Anesthetic drug propofol inhibits the expression of interleukin-6, interleukin-8 and cyclooxygenase-2, a potential mechanism for propofol in suppressing tumor development and metastasis

作者：Li, Xuefeng; Li, Longyun; Liang, Feng; Liu, Guifeng^*; Zhao, Guoqing^*

来源：Oncology Letters, 2018, 15(6): 9523-9528.

DOI：10.3892/ol.2018.8515

• anesthesia drug
• propofol
• interleukin-6
• interleukin-8
• cyclooxygenase-2
• antitumor mechanism

Previous studies have indicated that anesthesia-associated drugs may directly inhibit cellular immunity and humoral immunity, which may be associated with tumor recurrence. The present study demonstrated that propofol may suppress the proliferation of MCF-7 cells and inhibit the expression of interleukin (IL)-6 and IL-8. Subsequent to treatment with propofol, MCF-7 cells demonstrated downregulated cyclooxygenase-2 (COX-2) protein expression and decreased levels of vascular endothelial growth factor and prostaglandin E2 in the supernatant. Therefore, the mechanism of propofol in suppressing tumor development and metastasis may be associated with the inhibition of IL-6, IL-8 and COX-2.

• 出版日期2018-6
• 单位吉林大学