科研之友
微信
新浪微博
Facebook
分享链接
摘要
Background: Oppositional defiant disorder (ODD) is a behavioral disorder that mainly refers to a recurrent pattern of disobedient, defiant, negativistic and hostile behaviors toward authority figures. Previous studies have showed associations of serotonin transporter (5-HTT) and monoamine oxidase A (MAOA) with behavioral and psychiatric disorders. The purposes of this study were to investigate the potential association of 5-HTT gene promoter polymorphism (5-HTTLPR) and MAOA gene polymorphism with susceptibility to ODD in a Han Chinese school population. Methods: The 5-HTTLPR gene polymorphism and the MAOA gene polymorphism were genotyped in a case-control study of 257 Han Chinese children (123 ODD and 134 healthy controls). Results: There was significant difference in the allele distribution of 5-HTTLPR (chi(2) = 7.849, P= 0.005) between the ODD and control groups. Further, there were significant differences in genotype (chi(2)=5.168, P=0.023) and allele distributions (chi(2)=10.336, P=0.001) of the MAOA gene polymorphism that is variable-number tandem repeat (MAOA-uVNTR) between two groups. Moreover, there were significant differences in genotype (chi(2)=4.624, P= 0.032) and allele distributions (chi(2)=9.248, P=0.002) of MAOA-uVNTR only in the male ODD and healthy groups. Conclusions: Our results suggest that 5-HTTLPR and MAOA-uVNTR gene variants may contribute to susceptibility to ODD. Further, MAOA-uVNTR gene polymorphism may play a role in susceptibility to ODD only in male children.
