APOE epsilon 4 increases the risk of progression from amnestic mild cognitive impairment to Alzheimer's disease among ethnic Chinese in Taiwan

作者：Wang Pei Ning^*; Hong Chen Jee; Lin Ker Neng; Liu Hsiu Chih; Chen Wei Ta

来源：Journal of Neurology Neurosurgery and Psychiatry, 2011, 82(2): 165-169.

DOI：10.1136/jnnp.2010.209122

Objective To evaluate the effect of the apolipoprotein E (APOE) epsilon 4 in the progression from mild cognitive impairment (MCI) to Alzheimer's disease (AD) in ethnic Chinese people in Taiwan.
Methods Subjects older than 60 years with normal cognition, MCI or AD were enrolled from the memory clinic from 2000 to 2008. Normal ageing and MCI subjects were evaluated with clinical and neuropsychological examinations annually, and their APOE genotypes were determined.
Results A total of 326 normal ageing subjects, 304 amnestic MCI and 537 AD patients were recruited at baseline. The frequencies of APOE epsilon 4 were 22.1% in normal ageing, 26.6% in MCI and 40.8% in AD patients. During the follow-up period (42.5 +/- 18.5 months), there were 227 MCI patients, and 248 normal ageing subjects received one or more annual follow-up evaluation. The epsilon 4 +carriers had a higher annual conversion rate than did the epsilon 4-negative subjects either in the MCI (15.9% vs 9.0%) or in the normal ageing subjects (2.2% vs 0.7%). The mean survival time before progression to AD was 57.0 months for the MCI epsilon 4+ carriers, 85.9 months for MCI epsilon 4-negative patients, 86.2 months for normal ageing e4+ carriers and 120.8 months for normal ageing epsilon 4-negative subjects. The adjusted hazard ratio of APOE epsilon 4 for developing AD was 2.0 (95% CI 1.2 to 3.2) in MCI and 5.3 (95% CI 1.2 to 24.1) in normal ageing.
Conclusion APOE epsilon 4 increased the risk of developing AD both in amnestic MCI and in normal ageing in a clinic-recruited ethnic Chinese population.

• 出版日期2011-2