Anti-inflammatory activity of chondroitin sulfate

作者：Lovu M; Dumais G; du Souich P^*

来源：Osteoarthritis and Cartilage, 2008, 16: S14-S18.

DOI：10.1016/j.joca.2008.06.008

• Chondroitin sulfate
• Disaccharides
• Osteoarthritis
• Inflammation
• NF-kB
• Signal transduction

Osteoarthritis is primarily characterized by areas of destruction of articular cartilage and by synovitis. Articular damage and synovitis are secondary to local increase of pro-inflammatory cytokines (interleukin-1 beta) and tumor necrosis factor-of), enzymes with proteolytic activity (matrix metalloproteinases), and enzymes with pro-inflammatory activity (cyclooxygenase-2 and nitric oxide synthase-2). Enhanced expression of these proteins in chondrocytes and in synovial membrane appears associated to the activation and nuclear translocation of nuclear factor-kappa B (NF-kappa B). Chondroitin sulfate (CS) prevents joint space narrowing and reduces joint swelling and effusion. To produce these effects, CS elicits an anti-inflammatory effect at the chondral and synovial levels. CS and its disaccharides reduce NF-kappa B nuclear translocation, probably by diminishing extracellular signal-regulated kinase-1/2, p38mitogen-activated protein kinase and c-Jun N-terminal kinase activation. This review discusses the evidence supporting that CS pleiotropic effects in chondrocytes and synoviocytes are primarily due to a common mechanism, e.g., the inhibition of NF-kappa B nuclear translocation.

• 出版日期2008-10