An Easy Approach for the Synthesis of N-Substituted Isoindolin-1-ones

作者：Ordonez Mario^*; Tibhe Gaurao D; Zamudio Medina Angel; Viveros Ceballos Jose Luis

来源：Synthesis, 2012, 44(4): 569-574.

DOI：10.1055/s-0031-1289680

• amino phosphonates
• isoindolinones
• C-P cleavage
• microwave irradiation
• one-pot reaction

A practical and efficient two-step synthesis of N-substituted isoindolin-1-ones was developed. The one-pot reaction of 2-formylbenzoic acid with amines and dimethyl phosphite proceeds in short time either with conventional heating or microwave irradiation under catalyst-free conditions to afford the corresponding N-substituted dimethyl 3-oxoisoindolin-1-ylphosphonates in good yield which, by means of a dephosphonylation reaction with lithium aluminum hydride, give the target N-substituted isoindolin-1-ones in moderate to good yield.

• 出版日期2012-2