A convenient and practical method for the selective preparation of deuterofluorocarbons

作者：Richardson David P^*; Bauer Gordon S; Bravo Andrew A; Drzyzga Michael; Motazedi Tina; Pelegri O'Day Emma M; Poudyal Shirish; Suess Daniel L M; Thoman John W Jr

来源：Journal of Fluorine Chemistry, 2015, 180: 208-215.

DOI：10.1016/j.jfluchem.2015.10.002

• Deuteration
• Perfluoroalkanes
• Deuteroperfluroroalkanes
• Iodoperfluoroalkanes
• Zinc
• Zinc chloride
• F-19 NMR spectroscopy

A detailed study of the development of efficient and practical conditions for the selective synthesis of 1-deuterononafluorobutane from 1-iodononafluorobutane is reported. The optimal conditions involve treatment of the iodo-precursor in D2O at similar to 170 degrees C in the presence of metallic zinc in a sealed Schlenk tube to give a 59% yield of 1-deutero-1,12,2,3,3,4,4,4-nonafluorobutane. The same method was applied successfully to two higher homologues to produce 1-deutero-1,1,2,2,3,3,4,4,5,5,5-undecafluoropentane and 1-deutero-1,1,2,2,32,4,4,5,5,6,6,6-tridecafluorohexane in yields of 64% and 56%, respectively. Surprisingly, even the non-perfluorinated product 6-deutero-1,1,1,2,2,3,3,4,4-nonafluorohexane could be synthesized in 69% yield with this method.

• 出版日期2015-12