Aryne cycloaddition with 3-oxidopyridinium species

作者：Ren, Hailong; Wu, Chunrui; Ding, Xiuxiu; Chen, Xiaoge; Shi, Feng^*

来源：Organic and Biomolecular Chemistry, 2012, 10(45): 8975-8984.

DOI：10.1039/c2ob26519b

• 6-MEMBERED AROMATIC RINGS
• GONG-TENG-A
• 1,3-DIPOLAR CHARACTER
• BETAINE CYCLOADDITION
• DIPOLAR CYCLOADDITION
• HETISINE ALKALOIDS
• SYNTHETIC ACCESS
• TRICYCLIC CORE
• BENZYNE
• 3-HYDROXYPYRIDINE

The [3 + 2] cycloaddition of arynes with 3-oxidopyridinium species is examined using the Kobayashi benzyne precursor. The reaction affords a bicyclo[3.2.1] skeleton under mild conditions. A [7 + 2] cycloaddition mode with a subsequent pyridine ring-opening event has also been observed.

• 出版日期2012
• 单位河南大学