Novel fullerene derivatives as dual inhibitors of Hepatitis C virus NS5B polymerase and NS3/4A protease

作者：Kataoka Hiroki; Ohe Tomoyuki^*; Takahashi Kyoko; Nakamura Shigeo; Mashino Tadahiko^*

来源：Bioorganic & Medicinal Chemistry Letters, 2016, 26(19): 4565-4567.

DOI：10.1016/j.bmcl.2016.08.086

• Fullerene
• Hepatitis C virus (HCV)
• NS3/4A protease
• NS5B polymerase

We evaluated the Hepatitis C virus (HCV) NS5B polymerase and HCV NS3/4A protease inhibition activities of a new set of proline-type fullerene derivatives. All of the compounds had the potential to inhibit both the enzymes, indicating that the fullerene derivatives may be dual inhibitors against NS5B and NS3/4A and could be novel lead compounds for the treatment of HCV infections.

• 出版日期2016-10-1