Molecular Cytogenetic Analysis of a Gliosarcoma with Osseous Metaplasia

作者：Dahlback H S S^*; Gorunova L; Micci F; Scheie D; Brandal P; Meling T R; Heim S

来源：Cytogenetic and Genome Research, 2011, 134(2): 88-95.

DOI：10.1159/000326804

• Array CGH
• FISH
• Gliosarcoma
• Karyotyping
• t(3
• 21)

Gliosarcoma, a rare glioblastoma variant, is composed of a glial and a mesenchymal component. Though the mesenchymal portion most commonly resembles a fibrosarcoma, other differentiation patterns have been observed. We present the first genomic characterisation (karyotyping followed by FISH and array comparative genomic hybridisation analysis) of a gliosarcoma with osseous metaplasia. In addition to chromosomal changes often found in gliomas (+7,-10,-13, and -22), the tumour cells also harboured a hitherto unknown t(3;21)(q13 similar to 21;q21 similar to 22).

• 出版日期2011
• 单位河北医科大学