科研之友
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摘要
A nanoscale probe of calcium phosphate enclosed liposomes filled with sulforhodamine B (SRB) aqueous solution was synthesized, and the degradation of SRB in the probes was used to measure the enhanced energy deposition within the nanoscale probes after mixing them with PEGylated gold nanoparticles under X-ray irradiation. The enhancement was measured as a function of the gold nanoparticle concentration, and the results showed a surprising jump at 0.46 nM of gold nanoparticles with a steep slope of 42-fold per one weight percentage (wp(-1)) of gold in water superimposed on a gentle 1-fold wp(-1) slope. Theoretical simulations revealed that the jump was caused by the previously proposed type 2 physical enhancement (T2PE) exerted from a single 90 nm gold nanoparticle on a contacting nanoscale probe, and the gentler slope by type 1 physical enhancement (T1PE) was caused by the rest of the gold nanoparticles hundreds of nanometers or farther away. The jump is equivalent to a 2-fold absolute enhancement for each nanoscale probe. This assignment also suggests that T1PE and T2PE obey the addition algorithm. The use of nanoscale probes creates a framework of X-ray-induced energy transfer in which both T1PE and T2PE can be understood as energy transfer from gold nanoparticle donors to nanoscale probe acceptors.
- 出版日期2016-2-11
