Aza-[1,2]-Wittig rearrangements of N-benzyl glycine methyl esters. A new approach to the synthesis of N-aryl phenylalanine derivatives

作者：Everett Renata K; Wolfe John P^*

来源：Tetrahedron Letters, 2015, 56(23): 3393-3395.

DOI：10.1016/j.tetlet.2015.01.037

• Boron
• Wittig rearrangement
• Enolate
• Heterocycle

Treatment of N-(arylmethyl)-N-aryl glycine methyl ester derivatives with Bu2BOTf and (Pr2NEt)-Pr-i effects an aza-[1,2]-Wittig rearrangement that provides N-aryl phenylalanine methyl esters in good yields. Analogous substrates bearing N-carbonyl groups are converted to 1,4,2-oxazaborole derivatives under similar conditions.

• 出版日期2015-6-3