Application of RNA interference in treating human diseases

作者：Angaji S Abdolhamid^*; Hedayati Sara Sadate; Poor Reihane Hosein; Madani Safoura; Poor Sanaz Samad; Panahi Samin

来源：Journal of Genetics, 2010, 89(4): 527-537.

• gene silencing
• RNAi
• human diseases

Gene silencing can occur either through repression of transcription, termed transcriptional gene silencing (TGS), or through translation repression and mRNA degradation, termed posttranscriptional gene silencing (PTGS). PTGS results from sequence-specific mRNA degradation in the cytoplasm without dramatic changes in transcription of corresponding gene in nucleus. Both TGS and PTGS are used to regulate endogenous genes. Interestingly, mechanisms for gene silencing also protect the genome from transposons and viruses. In this paper, we first review RNAi mechanism and then focus on some of its applications in biomedical research such as treatment for HIV, viral hepatitis, cardiovascular and cerebrovascular diseases, metabolic disease, neurodegenerative disorders and cancer.

• 出版日期2010-12