Antioxidative/Acetylcholinesterase Inhibitory Activity of Some Asteraceae Plants

作者：Mekinic Ivana Generalic^*; Burcul Franko; Blazevic Ivica; Skroza Danijela; Kerum Daniela; Katalinic Visnja

来源：Natural Product Communications, 2013, 8(4): 471-474.

• Asteraceae
• Rosmarinic acid
• HPLC
• Antioxidant activity
• Acetylcholinesterase inhibition

The extracts obtained by 80% EtOH from some Asteraceae plants (Calendula officinalis, Inula helenium, Arctium lappa, Artemisia absinthium and Achillea millefolium) were studied. Rosmarinic acid, one of the main compounds identified in all extracts, was determined quantitatively by using HPLC. In addition, spectrophotometric methods were evaluated as an alternative for rosmarinic acid content determination. Total phenolic content was also established for all extracts. A. millefolium extract was found to have the highest content of rosmarinic acid as well as total phenols. All extracts were tested for antioxidant and acetylcholinesterase inhibitory activity. A. millefolium was shown to possess the best antioxidant activity (for all tested methods) as well as acetylcholinesterase inhibitory activity. Highly positive linear relationships were obtained between antioxidant/acetylcholinesterase inhibitory activity and the determined rosmarinic acid content indicating its significance for the observed activities.

• 出版日期2013-4