Association between dietary inflammatory potential and breast cancer incidence and death: results from the Women%26apos;s Health Initiative

作者：Tabung Fred K; Steck Susan E; Liese Angela D; Zhang Jiajia; Ma Yunsheng; Caan Bette; Chlebowski Rowan T; Freudenheim Jo L; Hou Lifang; Mossavar Rahmani Yasmin; Shivappa Nitin; Vitolins Mara Z; Wactawski Wende Jean; Ockene Judith K; Hebert James R

来源：British Journal of Cancer, 2016, 114(11): 1277-1285.

DOI：10.1038/bjc.2016.98

• dietary inflammatory index
• breast cancer
• incidence
• mortality
• Women's Health Initiative

Background: Diet modulates inflammation and inflammatory markers have been associated with cancer outcomes. In the Women's Health Initiative, we investigated associations between a dietary inflammatory index (DII) and invasive breast cancer incidence and death.
Methods: The DII was calculated from a baseline food frequency questionnaire in 122 788 postmenopausal women, enrolled from 1993 to 1998 with no prior cancer, and followed until 29 August 2014. With median follow-up of 16.02 years, there were 7495 breast cancer cases and 667 breast cancer deaths. We used Cox regression to estimate multivariable-adjusted hazards ratios (HRs) and 95% confidence intervals (95% CIs) by DII quintiles (Q) for incidence of overall breast cancer, breast cancer subtypes, and deaths from breast cancer. The lowest quintile (representing the most anti-inflammatory diet) was the reference.
Results: The DII was not associated with incidence of overall breast cancer (HRQ5vsQ1, 0.99; 95% CI, 0.91-1.07; P-trend = 0.83 for overall breast cancer). In a full cohort analysis, a higher risk of death from breast cancer was associated with consumption of more pro-inflammatory diets at baseline, after controlling for multiple potential confounders (HRQ5vsQ1, 1.33; 95% CI, 1.01-1.76; P-trend = 0.03).
Conclusions: Future studies are needed to examine the inflammatory potential of post-diagnosis diet given the suggestion from the current study that dietary inflammatory potential before diagnosis is related to breast cancer death.

• 出版日期2016-5-24
• 单位西北大学; UCLA