A Meta-Analysis of Circulating Microvesicles in Patients with Myocardial Infarction

作者：Wang Zhida; Cai Wang; Hu Shaolan; Xia Yufei; Wang Yao; Zhang Qi^*; Chen Liming^*

来源：Arquivos Brasileiros de Cardiologia, 2017, 109(2): 156-163.

DOI：10.5935/abc.20170102

• Myocardiaol Infarction
• Biomarkers
• Cell-Derived Microparticles
• Annexion A5
• Blood Platelets
• Leukocytes
• Endothelium

Background: Cell-derived microvesicles (MVs) are vesicles released from activated or apoptotic cells. However, the levels of MVs in myocardial infarction have been found inconsistent in researches.
Objective: To assess the association between MVs and myocardial infarction by conducting a meta-analysis.
Methods: A systematic literature search on PubMed, Embase, Cochran, Google Scholar electronic database was conducted. Comparison of the MVs levels between myocardial infarction patients and healthy persons were included in our study. Standard Mean Difference (SMD) and 95% confidence interval (CI) in groups were calculated and meta-analyzed.
Results: 11 studies with a total of 436 participants were included. Compared with the health persons, AMVs [SMD = 3.65, 95% CI (1.03, 6.27)], PMVs [SMD = 2.88, 95% CI (1.82, 3.93),] and EMVs [SMD = 2.73, 95% CI (1.13, 4.34)], levels were higher in patients with myocardial infarction. However, LMVs levels [SMD = 0.73, 95% CI (-0.57, 2.03)] were not changed significantly in patients with myocardial infarction.
Conclusions: AMVs, PMVs and EMVs might be potential biomarkers for myocardial infarction.

• 出版日期2017-8
• 单位天津医科大学