Alternative Mitochondrial Fuel Extends Life Span

作者：Schroeder Elizabeth A; Shadel Gerald S^*

来源：Cell Metabolism, 2012, 15(4): 417-418.

DOI：10.1016/j.cmet.2012.03.011

In this issue of Cell Metabolism, Ristow and colleagues (Zarse et al., 2012) elucidate a conserved mechanism through which reduced insulin-IGF1 signaling activates an AMP-kinase-driven metabolic shift toward oxidative proline metabolism. This, in turn, produces an adaptive mitochondrial ROS signal that extends worm life span. These findings further bolster the concept of mitohormesis as a critical component of conserved aging and longevity pathways.

• 出版日期2012-4-4