MTHFR C677T polymorphism and migraine risk: A meta-analysis

作者：Liu, Ruozhuo; Geng, Peiliang; Ma, Minghui; Yu, Shengyuan^*; Yang, Minghui; He, Mianwang; Dong, Zhao; Zhang, Wei

来源：Journal of the Neurological Sciences, 2014, 336(1-2): 68-73.

DOI：10.1016/j.jns.2013.10.008

• MTHFR
• Migraine with aura
• Migraine without aura
• C677T polymorphism
• Meta-analysis

Many molecular epidemiological studies were carried out in recent years to assess the association between the MTHFR C677T polymorphism and migraine risk in diverse populations. However, the results remain controversial rather than conclusive. The objective of this study was to investigate the role of C677T MTHFR polymorphism in migraine pathogenesis. We performed a meta-analysis of published case-control studies concerning the association of the C677T MTHFR polymorphism and migraine. Pooled ORs were established using both random and fixed effects models. This meta-analysis on 17 studies with 8903 cases and 27,637 controls showed that the allele 677T was associated with a significantly increased risk of total migraine in Asians (TT vs. CT + CC: OR = 1.62, 95% CI: 1.13-232, P-H = 0.573, I-2 = 0.0%; T vs. C: OR = 1.18, 95% CI: 1.00-1.40, PH = 0.147, I-2 = 44.1%). Similar results were also presented in Asian populations with MA (TI' vs. CC: OR = 1.62, 95% CI: 1.11-3.75; TT vs. CT + CC: OR = 2.00, 95% CI: 1.01-3.95; T vs. C: OR = 1.31, 95% CI: 1.02-1.69) without significant heterogeneity. We conclude that the C677T MTHFR polymorphism, responsible for a reduction of the MTHFR activity in folate metabolism, may act as a genetic susceptibility factor for migraine, MA in particular among the subjects of Asian descent.

• 出版日期2014-1-15
• 单位中国人民解放军军事医学科学院; 中国人民解放军总医院