Photobiostimulation effect on diabetic wound at different power density of near infrared laser

作者：Lau PikSuan; Bidin Noriah^*; Krishnan Ganesan; AnaybBaleg Saria Mohammed; Sum Mohamad Bin Md; Bakhtiar Hazri; Nassir Zaleha; Hamid Asmah

来源：Journal of Photochemistry and Photobiology B: Biology , 2015, 151: 201-207.

DOI：10.1016/j.jphotobiol.2015.08.009

• Photobiostimulation
• Diode laser
• Diabetic
• Therapy
• Histological
• Wound healing

The photobiostimulation effects of near infrared 808 nm diode laser irradiance on diabetic wound were investigated. 120 rats were induced with diabetes by streptozotocin injection. Full thickness punch wounds of 6 mm diameter were created on the dorsal part of the rats. All rats were randomly distributed into four groups; one group served as control group, whereas three groups were stimulated daily with unchanged energy density dose of 5 J/cm(2) with different power density, which were 0.1 W/cm(2), 0.2 W/cm(2) and 0.3 W/cm(2) with different exposure duration of 50 s, 25 s and 17 s, respectively. Ten rats from each group were sacrificed on day 3, 6 and 9, respectively. Skin tissues were removed for histological purpose. The contraction of wound was found optimized after exposure with 0.1 W/cm(2). Based on the histological evidence, laser therapy has shown able to promote wound repair through enhanced epithelialization and collagen fiber synthesis. Generally, irradiated groups were advanced in terms of healing than non-irradiated group.

• 出版日期2015-10