A New Complex of Palladium(II) With 2-Furoic Hydrazide: Synthesis, Characterization, Theoretical Calculations and Biological Studies

作者：de Souza Gustavo Duarte; Rodrigues Monica Aparecida; Silva Priscila Pereira; Pereira Maia Elene Cristina; Botelho Francoise Vasconcelos; de Campos Tatiana Amabile; Franca Eduardo de Faria; de Almeida Katia Julia; Guerra Wendell^*

来源：Croatica Chemica Acta, 2013, 86(2): 201-206.

DOI：10.5562/cca2151

• palladium complexes
• hydrazides
• hydrazones
• DFT studies
• antibacterial activity

A new complex of palladium was isolated with 2-furoic hydrazide (FH) and characterized by spectroscopic methods. The results show that the ligand is coordinated to palladium by the basic nitrogen of NH2 group and has a general structure of type cis-[Pd(FH)(2)Cl-2]. The structure of palladium(II) complex was optimized and theoretical data show good agreement with the experimental results. The cytotoxic activity was evaluated in a chronic myelogenous leukemia cell line, which revealed that the compound is less active than cisplatin or carboplatin. At 300 mu g mL(-1), the complex presented antimicrobial activity more efficient than ampicillin, chloranfenicol and kanamicyn.

• 出版日期2013-7