Azlactone-based heterobifunctional linkers with orthogonal clickable groups: efficient tools for bioconjugation with complete atom economy.

作者：Ho Hien The; Bénard Alexandre; Forcher Gwenal; Le Bohec Mal; Montembault Véronique; Pascual Sagrario; Fontaine Laurent

来源：Organic and Biomolecular Chemistry, 2018, 16(39): 7124-7128.

DOI：10.1039/c8ob01807c

We report the efficient synthesis of a series of new azlactone-based heterofunctional linkers bearing two orthogonal clickable groups that proceed with full atom economy. These new linkers comprise an azlactone (oxazolone) group that quickly reacts with amino groups in biologically relevant medium w...

• 出版日期2018